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| primary two, ctatarget sametab two, ctaexitinterstitial select two)                                                   |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
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|                                                                                                                       |
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|                                                                                                                       |
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| ![][image0]                                                                                                           |
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| ![][image1]                                                                                                           |
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| center center                                                                                                         |
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| center center                                                                                                         |
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| desktopPlacement-center                                                                                               |
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| mobilePlacement-bottom                                                                                                |
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| backgroundColor  | background-none |
+------------------+-----------------+
| textColor        | auto            |
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+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| # **イムルリオについて**                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| **イムルリオは、エストロゲン受容体（ER）とエストロゲンの結合を妨げるとともに、ERを分解することで、がん細胞の増殖を抑え、がんを小さくするお薬です。**                                       |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
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|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+

+---------------------------------------+
| Section Metadata                      |
+-------------------+-------------------+
| backgroundOption  | color             |
+-------------------+-------------------+
| backgroundColor   | background-custom |
+-------------------+-------------------+
| textColor         | auto              |
+-------------------+-------------------+
| additionalPadding | narrow            |
+-------------------+-------------------+

---

+----------------------------------------------------------------------------------------------------------------------+
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| light two, ctastyle primary two, ctatarget sametab two, ctaexitinterstitial select two)                              |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| ## **ホルモン受容体陽性乳がんの増え方とホルモン療法**                                                                                       |
+----------------------------------------------------------------------------------------------------------------------+
| ホルモン受容体陽性の乳がんでは、ERにエストロゲンが結合することで、がん細胞が増殖します。\                                                                       |
| ホルモン療法はエストロゲンを減らしたり、エストロゲンがERと結合するのを妨げたりして、がん細胞の増殖を抑えます。                                                             |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+

+----------------------------------+
| Image Block (none, desc bg none) |
+----------------------------------+
| ![ESR1遺伝子が変異する前のイメージ][image2]    |
+----------------------------------+
| ![ESR1遺伝子が変異する前のイメージ][image2]    |
+----------------------------------+
|                                  |
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|                                  |
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|                                  |
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+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
| *ESR1*遺伝子が変異するとERの働きが変わり、エストロゲンがなくても、がん細胞が増殖します。\                                                                     |
| そのため、*ESR1*遺伝子が変異した後は、ホルモン療法が効きにくくなります。                                                                               |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+

+----------------------------------+
| Image Block (none, desc bg none) |
+----------------------------------+
| ![ESR1遺伝子が変異した後のイメージ][image3]    |
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| ![ESR1遺伝子が変異した後のイメージ][image3]    |
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|                                  |
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|                                  |
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+-------------------+-----------------+
| textColor         | auto            |
+-------------------+-----------------+
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+-------------------+-----------------+

---

+----------------------------------------------------------------------------------------------------------------------+
| Text Component (alignment left, title fs 32px, description fs 16px, ctanumber one, ctatype button, ctacolor light,   |
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+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| ## **イムルリオの作用**                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| イムルリオは、*ESR1*遺伝子が変異した乳がんのERに結合することで、 エストロゲンの働きを妨げるだけでなく、ERを分解し、がん細胞の増殖を抑えます。                                         |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+

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| Spacer And Divider (divider, small, contrast, small one) |
+----------------------------------------------------------+
|                                                          |
+----------------------------------------------------------+

+----------------------------------+
| Image Block (none, desc bg none) |
+----------------------------------+
| ![イムルリオの作用のイメージ][image4]         |
+----------------------------------+
| ![イムルリオの作用のイメージ][image4]         |
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|                                  |
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| true                             |
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|                                  |
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|                                  |
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|                                                          |
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| ctastyle primary two, ctatarget sametab two, ctaexitinterstitial select two)                                          |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
| Jeselsohn R, et al. Clin Cancer Res. 2014; 20（7）: 1757-1767.\                                                         |
| Bhatia N, et al. Eur J Med Chem. 2023; 256: 115422.                                                                   |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+

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| Section Metadata                      |
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+----------------------------------------------------------------------------------------------------------------------+
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| light two, ctastyle primary two, ctatarget sametab two, ctaexitinterstitial select two)                              |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
| ## **遺伝子検査**                                                                                                         |
+----------------------------------------------------------------------------------------------------------------------+
| *ESR1*遺伝子の変異があるかどうかは、イムルリオを使用する前に行う遺伝子検査で確認することができます。                                                                |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                      |
+----------------------------------------------------------------------------------------------------------------------+

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---

+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
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+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
|                                                                                                                                                                        |
+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
| ### **\_ホルモン療法薬と *ESR1* 遺伝子の変異との関係は？\_**                                                                                                                               |
+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
| ホルモン療法薬は、ホルモン受容体陽性乳がん患者さんに使用するお薬です。しかし、治療を続けるうちにお薬が効きにくくなることがあり、その原因のひとつに *ESR1* 遺伝子の変異があります。ホルモン療法を受けたことのある再発・転移乳がん患者さんの約40〜50％に、この変異が見つかったという報告があります<sup>1,2）</sup>。 |
+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
|                                                                                                                                                                        |
+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+
|                                                                                                                                                                        |
+------------------------------------------------------------------------------------------------------------------------------------------------------------------------+

+----------------------------------------+
| Image Block (none, desc bg none)       |
+----------------------------------------+
| ![ホルモン療法薬とESR1遺伝子の変異との関係のイメージ][image5] |
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| ![ホルモン療法薬とESR1遺伝子の変異との関係のイメージ][image6] |
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|                                        |
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+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
| 1）Bhave MA, et al. Breast Cancer Res Treat. 2024; 207（3）: 599-609.\                                                   |
| 2）Zundelevich A, et al. Breast Cancer Res. 2020; 22（1）: 16.                                                           |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
+-----------------------------------------------------------------------------------------------------------------------+
|                                                                                                                       |
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+----------------------------------------------------------------------------------------------------------------------+
| Metadata                                                                                                             |
+--------------------------+-------------------------------------------------------------------------------------------+
| title                    | イムルリオについて｜「イムルリオ」を服用される患者さんとそのご家族のためのウェブサイト｜日本イーライリリー株式会社                                 |
+--------------------------+-------------------------------------------------------------------------------------------+
| navigationtitle          | イムルリオについて                                                                                 |
+--------------------------+-------------------------------------------------------------------------------------------+
| published-time           | 2026-10-29T11:06:43.651Z                                                                  |
+--------------------------+-------------------------------------------------------------------------------------------+
| description              | イムルリオを服用中の患者さん、またはそのご家族の方を対象に作成された情報提供サイトです。（運営：日本イーライリリー株式会社）イムルリオの情報を提供いたします。           |
+--------------------------+-------------------------------------------------------------------------------------------+
| modified-time            | 2026-10-20T08:11:32.385Z                                                                  |
+--------------------------+-------------------------------------------------------------------------------------------+
| storybanner-templatetype | default                                                                                   |
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| enablebreadcrumb         | true                                                                                      |
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+--------------------------+-------------------------------------------------------------------------------------------+

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